U.S. FDA announces Comfortis(R) and Ivermectin Interaction Safety Warning Notification June 24, 2008
Today the U.S. FDA Center for Veterinary Medicine (CVM) is announcing that is has received reports of adverse reactions in dogs receiving the drug Comfortis(R) (spinosad) concurrently with high, extra-label doses of ivermectin. The clinical sign of these adverse reactions are consistent with ivermectin toxicity.
Veterinarians who use high, extra-label doses of ivermectin to treat dogs with non-responsive demodectic mange and other conditions should be aware that some dogs have developed signs of ivermectin toxicity when ivermectin is used concurrently with Comfortis(R) (spinosad).
Elanco Animal Health, the manufacturer of Comfortis(R) (spinosad) and CVM are advising veterinarians that dogs receiving extra-label doses of ivermectin should not receive concurrent treatment with Comfortis(R) (spinosad).
Additional information regarding this safety warning can be obtained on the Elanco Animal Health website.